Endocrine Abstracts

ObjectiveTo describe a few cases of patients presenting with various unusual causes of hypercalcaemia to a District General Hospital.MethodsThree case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsIn the first case we describe an eighty year old patient recently started on lithium carbonate for mani...

ObjectiveTo describe two cases of patients presenting with abdominal pain to the gastroenterologists. These were diagnosed with primary hyperparathyroidism and adrenal insufficiency respectively.MethodsTwo case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsWe present a 62 year old gentleman who was ...

BackgroundRapid induction of eu/hypothyroidism in patients with immune hyperthyroidism has been known to precipitate Thyroid eye disease (TED). Our aim was to investigate the incidence of TED in patients treated with radio-iodine therapy (RIT) at our hospital.MethodsWe examined case notes of 45 patients who underwent radio-iodine therapy for Graves’ disease with 544.7 (95% CI- 522.3 – 567.1) MBq bet...

This 65 years old lady, who had undergone neck explorations for parathyroid adenoma in 1972 and 2000, presented with vomiting, lethargy, muscle weakness and polyuria. On admission, her serum Calcium was 2.98 mmol/l (2.18-2.63) with elevated parathyroid hormone of 151 pg/ml (10-70). A Thallium-Technetium parathyroid scan was normal but Octreotide scan showed an area of uptake in the superior mediastinum. A MIBI scan followed, which was unhelpful as were ultrasound scan of the n...

Patients who have Sr. Prolactin level >3000 mU/l (n=24) were selected from the Biochemistry laboratory record & patients with confirmed diagnosis of prolactinoma (n=33) identified and / followed up at Endocrine Clinic between December 1999 and October 2001 were studied. The mean age of the patients were 45.03+ 14.09 years and 72% were women. Of the patients diagnosed to have prolactinoma, 16 had microprolactinoma. 16 had macroprolactinoma and 1 had stalk disconnection. ...

Introduction: Adiposity has been well known to influence blood pressure. Adipokines are peptides secreted from the adipose tissue. TNF-alpha and IL-6 are pro-inflammatory adipokines while adiponectin and leptin have been known to be influencing vascular function. The influence of adipokines on blood pressure is not yet known. Our hypothesis was that all adipokines positively influenced both systolic and diastolic blood pressure.Patients and methods: One ...

Hyperthyroidism has a profound effect on the cardiovascular system. Heart failure is common in the elderly patients with hyperthyroidism who have co-existing cardiac disease.We report a case of severe heart failure in a 43-year-old woman with Graves' disease. She presented with cough and breathlessness for 3 weeks. There was a strong family history of thyroid disease. On presentation, she had florid hyperthyroidism with features of Graves' disease. Exam...

Introduction: The UK has seen a steady rise in childhood obesity over the last 30 years, with nearly a third of children aged 2–15 now overweight or obese. Childhood obesity represents a significant health burden, costing the NHS many millions of pounds.Aim: The aim of this study was to investigate the knowledge, perception and actions of obese patients at the Royal Manchester Children’s Hospital (RMCH), to guide recommendations for improving t...

CHI is a disorder of dysregulated insulin release characterised by severe recurrent hypoglycaemia. Mutations in genes encoding the beta-cell sulphonylurea receptor (ABCC8) and inward-rectifying potassium-channel (KCNJ11) are the commonest genetic cause of CHI, followed by that encoding glutamate dehydrogenase (GLUD-1). Histologically, disease pathology is subdivided into diffuse or focal disease; the latter associated with paternal mutations and somatic lo...

Previous research concerning the cognitive profile of children with CHI has identified a high incidence of significant learning difficulty (Rother et al. 2001, Jack et al. 2003). Both studies report an incidence of 30 to 50% cognitive skills within the learning disability range in both study populations. Furthermore, Rother et al. (2001) suggested that all children investigated demonstrated some form of cognitive difficulty, ranging from learning disabilit...